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Citation: Mossman D, Scott RJ (2011) Long Term Transcriptional Reactivation of Epigenetically Silenced Genes in Colorectal Cancer Cells Requires DNA Hypomethylation and Histone Acetylation. PLoS ONE 6(8): e23127. https://doi.org/10.1371/journal.pone.0023127
Editor: Michael Freitag, Oregon State University, United States of America
Received: December 16, 2010; Accepted: July 12, 2011; Published: August 4, 2011
Copyright: © 2011 Mossman, Scott. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This study was supported by funds from the NBN Telethon, the University of Newcastle and the Hunter Medical Research Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
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| Public (NASDAQ: VARI) | |
| Industry | Scientific instruments |
|---|---|
| Fate | Acquired by Agilent Technologies |
| Founded | 1999 |
| Headquarters | Palo Alto, California |
Key people | Allen J. Lauer, Chairman Garry Rogerson, President & CEO |
| Products | Scientific instruments |
| 3,700 | |
| Website | www.varianinc.com |
Varian, Inc. was one of the largest manufacturers of scientific instruments for the scientific industry. They had offerings over a broad range of chemical analysis equipment, with a particular focus on Information Rich Detection[clarification needed] and Vacuum technology. Varian was spun off from Varian Associates in 1999 and was purchased by Agilent Technologies in May 2010 for $1.5 billion, or $52 per share.[1]
Varian Inc. had its corporate headquarters in Palo Alto, California, and offices in Australia, the Benelux countries, Brazil, Canada, China, Germany, France, Italy, Japan, Korea, Russia, Sweden, Taiwan, the United Kingdom, and the United States.
Manufacturing Plants[edit]
Varian Inc. contained the following manufacturing plants:
Lake Forest, California USA
Palo Alto, California USA
Walnut Creek, California USA
Lexington, Massachusetts, USA
Cary, North Carolina, USA
Mulgrave, Victoria Australia (the largest Varian Inc manufacturing and R&D plant)
Middelburg, Netherlands
Grenoble, France
Yarnton, United Kingdom
Church Stretton, Shropshire, United Kingdom (polymer laboratories)
Turin, Italy
Products and services[edit]
Chromatography, including gas chromatography, GC/MS, high performance liquid chromatography, and LC/MS.
Spectroscopy, including UV-Vis, near infrared, and FT-IR
Inductively coupled plasma, including mass spectroscopic and atomic emission spectroscopic detection.
mass spectrometry, including FTMS
Nuclear magnetic resonance
Linear accelerator
Magnetic resonance imaging
X-ray Crystallography
Information rich detection
Drugs of Abuse Testing
Dissolution Testing
Vacuum Pumps
Leak Detection
Turbo Pumping Systems
Vacuum Measurement
Valves and components
History[edit]
In October 1967, Techtron Pty Ltd merged with Varian Associates. Techtron is a manufacturer of Atomic Absorption Spectrometers and Spectral lamps.
In 1982 Varian transferred the Cary UV-Visible product line to Australia.
In 2002 Varian bought Ansys Technologies, Inc., a California-based manufacturer of In-Vitro Medical Devices.
In 2004 Varian Inc bought Magnex Scientific, an Oxford-based manufacturer of high-field magnets.
In 2005 Varian bought Polymer Laboratories, a speciality polymer analysis and manufacturing company.
In 2006 Varian bought Ion Spec, an FTMS (Fourier Transform Mass Spectrometry) manufacturing company.
In 2007, Varian, Inc. bought Analogix, Inc., a company specializing in flash chromatography.
In 2008, Varian bought Oxford Diffraction, a British company specializing in X-ray diffraction equipment.[2]
On 27 July 2009 Agilent Technologies announced it would buy Varian Inc, for $1.5 Billion.
On 14 October 2014 Agilent made the strategic decision to close its NMR business. Agilent entered the NMR business in 2010, with the acquisition of Varian.[3]
See also[edit]
Varian Star Chromatography Workstation Manual Transmission Reviews
References[edit]
- ^''Agilent reaches deal to buy Varian for $1.5 billion' (Press release)'. Reuters. 2009-07-27. Retrieved 2009-07-27.
- ^''Varian, Inc. Acquires Oxford Diffraction, Ltd.' (Press release)'. Retrieved 2008-07-03.
- ^''Agilent Technologies to Close Nuclear Magnetic Resonance Business' (Press release)'.